Mitochondrial Respiratory Function Induces Endogenous Hypoxia
نویسندگان
چکیده
منابع مشابه
Mitochondrial Respiratory Function Induces Endogenous Hypoxia
Hypoxia influences many key biological functions. In cancer, it is generally believed that hypoxic condition is generated deep inside the tumor because of the lack of oxygen supply. However, consumption of oxygen by cancer should be one of the key means of regulating oxygen concentration to induce hypoxia but has not been well studied. Here, we provide direct evidence of the mitochondrial role ...
متن کامل0033. Hypothermia protects brain mitochondrial function from hypoxia in sepsis
Methods Mice (C57/bl6) were injected intraperitoneally with lipopolysaccharide (LPS) (5 mg/kg; n = 15) or saline (0.01 ml/g; n = 6). Six hours later, the cerebral cortex was exposed and mitochondrial function assessed using the inherent fluorescence of flavin adenine dinucleotide (FAD). The mice spontaneously breathed a sequence of 21% oxygen (room air), 100%, 21%, 15%, 21% and 10% for 5 minute...
متن کاملMitochondrial composition and function under the control of hypoxia
Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in r...
متن کاملImmunosuppressant deoxyspergualin affects mitochondrial respiratory function in growing cells.
experiments. DSGhas been found to interact intracelluarly with Hsc70, a constitutively expressed memberof the heat shock protein 70 (Hsp 70) family4), but the mechanism of action of DSGstill requires further explanation. We have used methyldeoxyspergualin (MeDSG) for in vitro culture studies of DSG, because it is more stable to hydrolysis than DSG but still possesses a similar immunosuppressive...
متن کاملDesmin Cytoskeleton Linked to Muscle Mitochondrial Distribution and Respiratory Function
Ultrastructural studies have previously suggested potential association of intermediate filaments (IFs) with mitochondria. Thus, we have investigated mitochondrial distribution and function in muscle lacking the IF protein desmin. Immunostaining of skeletal muscle tissue sections, as well as histochemical staining for the mitochondrial marker enzymes cytochrome C oxidase and succinate dehydroge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0088911